Dr Kalana Maduwage
Senior Lecturer - School of Science and Technology
Biography
Dr Kalana Maduwage is an academic with interests in medical teaching, biomedical research, research training and biomedical inventions. He obtained his medical degree (MBBS) at the University of Peradeniya, Sri Lanka and after working briefly as a junior clinician, went on to complete his MPhil in Biochemistry and Clinical Medicine (University of Peradeniya) and PhD at the University of Newcastle, Australia tutelage of Professor Geoff Isbister and Professor Wayne Hodgson. Within two years after completion of his PhD, he was promoted from Senior Lecturer to Professor in Biochemistry at University of Peradeniya, Sri Lanka in 2018 (at the age of 38).
In 2022 Dr Kalana joined the University of New England and is currently a tenured Senior Lecturer in Biomedical Science. Dr Kalana research has been focused on investigating the coagulopathy of snake envenomation and efficacy of antivenom treatment in snakebite envenomation. His research is focused on developing laboratory and rapid snake venom detection tests and clinical trials in snake envenomation. As a naturalist, he has contributed to discover 14 species of freshwater fish, 3 species of snakes and one lizard species from Sri Lanka.
Dr. Kalana has co-authored over 70 peer reviewed journal articles and 3 book chapters, delivered over 50 conference presentations and invited seminars. He is an author of three textbooks and the founder of web-based snakes identification service. There are three patents under his names for the inventing health related invention.
Qualifications
MBBS: University of Peradeniya, Sri Lanka
MPhil: (Biochemistry/Medicine), University of Peradeniya, Sri Lanka:
PhD (Clinical Pharmacology) Newcastle, Australia
Awards
2016. Finalist of Aspirin Social Innovation Award, Bayer Foundations, Berlin, Germany.
2014 Informa Health Care Award for the Best Platform Presentation paper presented at North American Conference of Clinical Toxicology (NACCT 2014), New Orleans, Louisiana, USA. “Diagnosis of snake envenoming using simple phospholipase A2 assay”.
2014 John Morris Scientific Award for the Best Overall Scientific Poster Presentation at the Australian Society for Medical Research (ASMR) Satellite Scientific Meeting, Newcastle, Australia for “Diagnosis of snake envenoming using simple phospholipase A2 assay”.
2014 ASMR Award for the Best Overall Scientific Poster Presentation at the Australian Society for Medical Research (ASMR) Meeting, Sydney, Australia for “Diagnosis of snake envenoming using simple phospholipase A2 assay”.
2021. Tire 4. Research Award (The highest), University of Peradeniya, Sri Lanka.
2016. CVCD (Committee of Vice-Chancellors and Directors) Excellence Award for the most outstanding young researcher in the field of medicine, dental, veterinary and allied sciences field in Sri Lanka offered by the HE president of Sri Lanka. I was the youngest awardee of this award who received it at the age of 36 years.
2018. Award of the Best Pre-Clinical Teacher, Faculty of Medicine, University of Peradeniya, Sri Lanka
2017. KSM (Kandy Society of Medicine) Health Research Prize of the year 2017.
2017 Three President’s Award for Scientific Publications. National Research Council (Awarded by the H.E. President of Sri Lanka).
2016 President’s Award for Scientific Publications. National Research Council (Awarded by the H.E. President of Sri Lanka).
2015 President’s Award for Scientific Publications. National Research Council (Awarded by the H.E. President of Sri Lanka).
2014 President’s Award for Scientific Publications. National Research Council (Awarded by the H.E. President of Sri Lanka).
2013 President’s Award for Scientific Publications. National Research Council (Awarded by the H.E. President of Sri Lanka).
2008 President’s Award for Scientific Publications. National Research Council (Awarded by the H.E. President of Sri Lanka).
2005 President’s Award for Scientific Publications. National Research Council (Awarded by the H.E. President of Sri Lanka).
2005 Presidential Award for the best invention of 2004: Invention of a Microscopic Slide Projector (Patent No: 12460).
2014. Award for the Best publication by the Physician at 48th Annual Academic Sessions, Colombo, for the publication titled “Revisiting Russell’s Viper (Daboia russelii) Bite in Sri Lanka: Is Abdominal Pain an Early Feature of Systemic Envenoming?”
2005 National Science Foundation Award for Young Scientists, 2005 (Undergraduate Category): Invention of a Microscopic Slide Projector (Patent No: 12460).
2012. National Research Council Merit Award for Scientific Publications, Sri Lanka.
2011. National Research Council Merit Award for Scientific Publications, Sri Lanka.
2010. National Research Council Merit Award for Scientific Publications, Sri Lanka.
2014. Research Publications Award, Faculty of Medicine, University of Peradeniya, Sri Lanka
2015. Research Publications Award, Faculty of Medicine, University of Peradeniya, Sri Lanka
2016. Research Publications Award, Faculty of Medicine, University of Peradeniya, Sri Lanka
2017. Research Publications Award, Faculty of Medicine, University of Peradeniya, Sri Lanka
2019. Research Publications Award, Faculty of Medicine, University of Peradeniya, Sri Lanka
2007 Ministry of Social Services and Social Welfare Award for outstanding performance as a young scientist, Sri Lanka.
2007 Awarded the B. H. Aluvihare Prize in Surgery for Final MBBS.
Teaching Areas
Clinical Biochemistry
Clinical and Experimental Pharmacology
Clinical Medicine
Physiology
Primary Research Area/s
Experimental Pharmacology/Toxinology; Snakebite envenomation; Antivenom treatment; Randomized controlled clinical trials; Diagnosis of envenomation; Fish and snake taxonomyResearch Interests
Clinical and experimental pharmacology/Toxicology
Research Supervision Experience
Ongoing MPhil supervisions
Ms. Chandima Pathiraja (MPhil)
Mrs. Sujeewa Jayasinghe (MPhil)
Mr. Sachintha Gamage (MPhil)
Miss. Jithmi Dinurangana (MPhil)
Publications
Silva A, Scorgie FE, Lincz LF, Maduwage K, Siribaddana S and Isbister GK (2022) Indian Polyvalent Antivenom Accelerates Recovery From Venom-Induced Consumption Coagulopathy (VICC) in Sri Lankan Russell’s Viper (Daboia russelii) Envenoming. Front. Med. 9:852651. doi: 10.3389/fmed.2022.852651.
K Maduwage, P Karunathilake, JM Gutiérrez 2021. Web-based snake identification service: A successful model of snake identification in Sri Lanka - Toxicon, 2021.11.11 https://doi.org/10.1016/j.toxicon.2021.11.007.
J Le Geyt, S Pach, JM Gutiérrez, AG Habib, KP Maduwage Paediatric snakebite envenoming: recognition and management of cases. Archives of disease in childhood, 2021. http://dx.doi.org/10.1136/archdischild-2020-319428.
José MaríaGutiérrez, Kalana Maduwage, Garba Iliyasu, Abdulrazaq Habib. (2021). Snakebite envenoming in different national contexts: Costa Rica, Sri Lanka, and Nigeria. Toxicon X. https://doi.org/10.1016/j.toxcx.2021.100066.
Subhankar Sarkar, Rajiv Sinha, Arpita Ray Chaudhury, Kalana Maduwage, Asiri Abeyagunawarde- na, Niladri Bose, Subal Pradhan, Nilzete Liberato Bresolin, Blenda Avelino Garcia, Mignon McCul- loch (2021) Snake bite associated with acute kidney injury Pediatr. Nephrol. 2021 Feb 9. doi: 10.1007/s00467-020-04911-x.
Maduwage KP, Gawarammana IB, Gutiérrez JM, Kottege C, Dayaratne R, Premawardena NP, et al. (2020) Enzyme immunoassays for detection and quantification of venoms of Sri Lankan snakes: Application in the clinical setting. PLoS Negl Trop Dis 14(10): e0008668. https://doi.org/ 10.1371/journal. pntd.0008668.
Maduwage K, Buddika H, Ranasinghe J, Wijesooriya K. (2020). Second case report of slender coral snake (Calliophis melanurus sinhaleyus) envenomation of Sri Lanka. Toxicon. 2021 Jan 15;189:7-9. DOI: 10.1016/j.toxicon.2020.10.023
Sophie Pach, Jacqueline Le Geyt, José María Gutiérrez, David Williams, Kalana Prasad Maduwage, Abdulrazaq Garba Habib, Rafael Gustin, María Luisa Avila-Agüero, Kyaw Thu Ya, Jay Halbert (2020). Paediatric snakebite envenoming: recognition and management of cases. Arch Dis Child 2020-319417. doi: 10.1136/archdischild-2020-319417.
Jacqueline Le Geyt, Sophie Pach, José María Gutiérrez, Abdulrazaq Garba Habib, Kalana Prasad Maduwage, Timothy Craig Hardcastle, Roger Hernández Diaz, María Luisa Avila-Aguero, Kyaw Thu Ya, David Williams, Jay Halbert. (2020). Paediatric snakebite envenoming: recognition and man- agement of cases. Arch Dis Child 2020-319428. DOI: 10.1136/archdischild-2020-319428.
Ratnayake I, Mohamed F, Buckley NA, Gawarammana IB, Dissanayake DM, Chathuranga U, Munasinghe M, Maduwage K, Jayamanne S, Endre ZH, Isbister GK. (2019). Early identification of acute kidney injury in Russell's viper (Daboia russelii) envenoming using renal biomarkers. PLoS Negl Trop Dis. 2019 Jul 1;13(7):e0007486. doi: 10.1371/journal.pntd.0007486.
Villalta M, Sampaio TL, de Menezes RRPPB, Lima DB, Jorge ARC, Alves RS, Monteiro HSA, Gawarammana I, Maduwage K, Malleappah R, León G, Martins AMC, Gutiérrez JM. (2019). Nephrotoxicity induced by the venom of Hypnale hypnale from Sri Lanka: Studies on isolated perfused rat kidney and renal tubular cell lines. Toxicon. 2019 Jul;165:40-46. doi: 10.1016/j.toxicon.2019.04.014.
Ratnayake I, Shihana F, Dissanayake DM, Buckley NA, Maduwage K, Isbister GK. (2017). Performance of the 20-minute whole blood clotting test in detecting venom induced consumption coagulopathy from Russell's viper (Daboia russelii) bites. Thromb Haemost. 2017 Feb 28;117(3):500-507. doi: 10.1160/TH16-10-0769.
Isbister GK, Jayamanne S, Mohamed F, Dawson AH, Maduwage K, Gawarammana I, Lalloo DG, de Silva HJ, Scorgie FE, Lincz LF, Buckley NA. (2017). A randomized controlled trial of fresh frozen plasma for coagulopathy in Russell's viper (Daboia russelii) envenoming. J Thromb Haemost. 2017 Apr;15(4):645-654. doi: 10.1111/jth.13628.
Maduwage, K. O’Leary, M. Silva, A. Isbister, GK. (2016). Detection of Snake Venom in Post-Antivenom Samples by Dissociation Treatment Followed by Enzyme Immunoassay. Toxins: 28: 8(5), E130. doi: 10.3390/toxins8050130.
Kalana Maduwage, Anjana Silva, Margaret A O’Leary, Wayne C Hodgson, Geoffrey K. Isbister. (2016). Efficacy of Indian polyvalent snake antivenom against Sri Lankan snake venoms: lethality studies or clinically focussed in vitro studies. Nature Scientific Reports. 6.26778. doi: 10.1038/srep26778 (2016).
Maduwage K, Scorgie F, Lincz, O’Leary, M. Isbister, GK. (2015). Procoagulant snake venoms have differential effects in animal plasmas: Implications for antivenom testing in animal models, Thrombosis Research, 137, 174-177. DOI: 10.1016/j.thromres.2015.12.002
Maduwage. K. Buckley, NA. de Silva, HJ. Lalloo, DG. Isbister, GK. (2015). Snake antivenom for snake venom induced consumption coagulopathy. Cochrane Database of Systematic Reviews Issue. 6 Art.No.:CD011428.DOI: 10.1002/14651858.CD011428.pub2.
Maduwage, K. O’Leary, MA. Scorgie, FE. Shahmy, S. Mohamed, F. Abeysinghe, C. Karunathilake, H. Lincz, L. Gnanathasan, CA. Isbister, GK. (2014). Detection of Venom after Antivenom Is Not Associated with Persistent Coagulopathy in a Prospective Cohort of Russell’s Viper (Daboia russelii) Envenomings. PLoS Neglected Tropical Diseases 8(12): e3304. doi:10.1371/journal.pntd.0003304.
Maduwage, K. Isbister, GK. (2014). Current Treatment for Venom-Induced Consumption Coagulopathy Resulting from Snakebite. PLoS Neglected Tropical Diseases. 8 (10): e3220. doi:10.1371/journal.pntd.0003220.
Maduwage K, O’Leary M, Isbister GK. (2014). Diagnosis of snake envenomation using a simple Phospholipase A2 assay. Nature Scientific Reports 4 (4827): DOI:10.1038/srep04827 (2014).
Kalana Maduwage, Fiona E. Scorgie, Seyed Shahmy, Fahim Mohamed, Chandana Abeysinghe, Harendra Karunathilake, Lisa F. Lincz, Christeine A. Gnanathasan, Geoffrey K. Isbister. (2013). Factor deficiencies in Hump-nosed pit viper (Hypnale hypnale) envenoming. Clinical Toxicology 51: 527-31.
Clinical Skills and Experience
MBBS (Peradeniya, Sri Lanka)
SLMC Registration as a general practitioner
10 years of experience working as a general practitioner
Internship in Pediatrics and Gynecology & Obstetrics
Memberships
Sri Lanka Medical Council (SLMC)
Fellow of Royal Society of Public Health FRSPH (UK)
Consultancy Interests
Commercial production of snake antivenom
