Dr Adam Hamlin
Senior Lecturer in Biomedical Science (Neuroscience) - School of Science and Technology
Phone: +61 02 6773 2579
Dr Hamlin joined the School of Science and Technology in 2014 as a Senior Lecturer in Biomedical Science (Neuroscience) moving from The School of Biomedical Sciences at Charles Sturt University where he was a Lecturer in Anatomy and Physiology. Prior to beginning his academic career in 2011 Dr Hamlin held a post-doctoral position at the Queensland Brain Institute, The University of Queensland where he was an NH&MRC Fellow investigating mechanisms of neurodegeneration in diseases such as Alzheimer's disease. Previously, he was a postdoctoral Fellow at The School of Psychology, The University of New South Wales where he was investigating the neural mechanisms that underpin relapse to drug seeking behaviours. Dr Hamlin gained his BSc (Honours) degree from the University of Queensland in 1999 and completed his PhD (Medicine) at The Pain Management Research Institute, The University of Sydney in 2006 examining the functional neuroanatomy of morphine-induced abstinence, tolerance and sensitisation.
BSSc (Psych), BSc (Hons), PhD (Medicine)
Dr Hamlin is passionate about science and science communication and takes the responsibility of educating very seriously. His teaching philosophy is to effectively communicate not just what we know but how we know with a particular emphasis on critical analysis of data.
It is Dr Hamlin's goal to develop the ability in his students to critically analyse information and formulate independent and valid hypotheses. It is his belief the making of a successful science student is not just knowing the facts but understanding how these conclusions were drawn by the examination of the experimental design and critical analysis of the results. He believes that education is a process that involves two sets of participants each playing a different role: Teachers who communicate their knowledge to students and students who absorb knowledge from teachers. However, education is also about students imparting knowledge to their teachers by challenging the teacher's assumptions through questioning. This is something that he encourages and he finds a particularly rewarding aspect of teaching.
Dr Hamlin is co-ordinator for the Bachelor of Science (Neuroscience) 3rd year units NEUR331 Neurobiology, NEUR332 Neuroanatomy, & NEUR333 Neurobiology II, and the Master of Neuroscience unit NEUR501 (Research Topics in Neuroscience). In addition Dr Hamlin teaches the neuroscience components of the 1st and 2nd year Joint Medical Program, Nursing, Biomedical Science and Pharmacy degrees.
The focus of my research combines sophisticated functional neuroanatomical analysis with behaviour, to elucidate the neurons, circuitry and chemical underpinnings of specific behaviours. Using a functional neuroanatomical approach in combination with behavioural designs Dr Hamlin has published several key papers relating to the functional significance of discrete neuronal populations and their circuitry. To date, this research has resulted in 22 research publications in high ranking international journals including, PLoS One, Journal of Neuroscience, Neurobiology of Learning and Memory, Behavioural Neuroscience, European Journal of Neuroscience, and Neuroimage. These research articles have been cited over 850 times (h index =17) and the recent publications elucidating a potential behavioural and MRI early detection system for Alzheimer's disease have been subject to wide spread national television radio and newspaper coverage.
Dr Hamlin has been invited to speak at several seminar series and symposia including; Neuroscience Seminar Series, Melbourne University; Translational Research 2010; 3rd Brain Plasticity Symposium: Circuits, Synapses and Behaviour; The Neuroscience Seminar Series, The University of Newcastle; Brain Sciences University of New South Wales Symposium; Australian Learning Group Christmas Workshop; Kolling Institute Seminar Series; and the XI Annual Royal North Shore Scientific Meeting as well as an invitation to speak at the inaugural Gene Regulation in Brain symposium. Dr Hamlin is a highly sought after public lecturer, having conducted lectures at libraries, bookshops, community groups, and University of the 3rd Age and have performed many television, radio and newspaper interviews. Dr Hamlin currently reviews for a number of international journals including: Neuroscience Letters, Polish Journal of Pharmacology, Brain Research, British Journal of Pharmacology, and Spinal Cord and is currently an NHMRC grant reviewer.
Current Research Projects
- Sensory Integration Therapy reverses neurodevelopmental, cognitive, emotional and social deficits in a rat model of chronic early life stress
- Exercise reverses neurodevelopmental, cognitive, emotional and social deficits in a rat model of chronic early life stress
- The effects of Chronic Early Life stress on the diversity of the gut microbiome.
- Development of novel antidepressant drugs
- Chronic early life stress’ association with gambling in later life
- Stuart Fisher (PhD Candidate)
- Chris George (Hons)
- Erin Bourke (Intern)
- Claudia Saab (Intern)
- Edwards, S. R., Hamlin, A. S., Marks, N., Coulson, E. J., & Smith, M. T. (2014). Comparative studies using the Morris water maze to assess spatial memory deficits in two transgenic mouse models of Alzheimer's disease. Clinical and Experimental Pharmacology and Physiology, 41(10), 798-806.
- Kerbler, G. M., Nedelska, Z., Fripp, J., Laczó, J., Vyhnalek, M., Lisý, J., Hamlin, A.S., Coulson, E. J. (2015). Basal forebrain atrophy contributes to allocentric navigation impairment in alzheimer’s disease patients. Frontiers in aging neuroscience, 7.
- Kamran, M., Hamlin, A. S., Scott, C. J., & Obied, H. K. (2015). Drying at high temperature for a short time maximizes the recovery of olive leaf biophenols. Industrial Crops and Products, 78, 29-38.
- Rose J.L., Hamlin A.S. and Scott C. J., Sex differences in the expression of estrogen receptor-α within noradrenergic neurons in the sheep brainstem, Dom Anim Endo; 10.1016/j.domaniend, 2014.
- Hamlin A.S., Windels F., Boskovic Z., Sah P. and Coulson E.J., Lesions of the basal forebrain cholinergic system in mice disrupt idiothetic navigation, PLoS One; 8 (1): e53472, 2013.
- Kerbler G.M., Hamlin A.S., Pannek K., Kurniawan N.D., Keller M.D., Rose S.E. and Coulson E.J., Diffusion-weighted magnetic resonance imaging detection of basal forebrain cholinergic degeneration in a mouse model. Neuroimage, 66C:133-141, 2012.
- Walker T.L., Vukovic J., Koudijs M.M., Blackmore D.G., Mackay E.W., Sykes A.M., Overall R.W., Hamlin A.S. and Bartlett P.F., Prolactin stimulates precursor cells in the adult mouse hippocampus, PLoS One ;7(9):e44371, 2012.
- Kim J.H., Li S., Hamlin A.S., McNally G. P, and Richardson R., Phosphorylation of mitogen-activated protein kinase in the medial prefrontal cortex and the amygdala following memory retrieval or forgetting in developing rats, Neurobiology of Learning and Memory, 97, 59-68, 2012.
- Furlong T.M., Cole S., Hamlin A.S. and McNally G.P., The role ofprefrontal cortex in predictive fear learning, Behavioural Neuroscience, 124, 574-86, 2010.
- Jhaveri D.J., Mackay E.W., Hamlin A.S., Marathe S.V., Nandam L.S., Vaidya V.A. and Bartlett P.F., Norepinephrine Directly Activates Adult Hippocampal Precursors via β3-Adrenergic Receptors. Journal of Neuroscience, 30, 2795-2806, 2010.
- Kim J.H., Hamlin A.S. and Richardson R., Fear extinction across development: the involvement of the medial prefrontal cortex as assessed by temporary inactivation and immunohistochemistry. Journal of Neuroscience, 29, 10802-8, 2009.
- Hamlin A.S., McNally G.P., Westbrook R.F. and Osborne P.B., Induction of Fos proteins in regions of the nucleus accumbens and ventrolateral striatum correlates with catalepsy and stereotypic behaviours induced by morphine. Neuropharmacology, 56, 798–807, 2009.
- Marchant N.J., Hamlin A.S. and McNally G.P., Lateral hypothalamus is required for context-induced reinstatement of extinguished reward seeking. Journal of Neuroscience, 29, 1331-42, 2009.
- Coulson E.J., May L.M., Sykes A.M. and Hamlin A.S., The role of the p75 neurotrophin receptor in cholinergic dysfunction in Alzheimer's disease. Neuroscientist, 15, 317-23, 2009.
- Hamlin A.S., Clemens K.J., Choi E.A., and McNally G.P., Paraventricular thalamus mediates context induced reinstatement (renewal) of extinguished reward seeking. European Journal of Neuroscience, 29, 802-12, 2009.
- Hamlin A.S., Clemens K.J. and McNally G.P., Renewal of extinguished cocaine seeking. Neuroscience, 151, 659-70, 2007.
- Hamlin A.S., McNally G.P. and Osborne P.B., Induction of c-Fos and zif268 in the nociceptive amygdala parallel abstinence hyperalgesia in rats briefly exposed to morphine. Neuropharmacology, 53, 330-343, 2007.
- Hamlin A.S., Newby J., McNally G.P., The neural correlates and role of D1 dopamine receptors in renewal of extinguished alcohol-seeking. Neuroscience, 146, 525-536, 2007.
- Hamlin A.S., Blatchford K.E. and McNally G.P., Renewal of an extinguished instrumental response: Neural correlates and the role of D1 dopamine receptors. Neuroscience, 143, 25-38, 2006.
- Buller K., Hamlin A.S. and Osborne P.B., Dissection of peripheral and central endogenous opioid modulation of systemic interleukin-1b responses using c-fos expression in the rat brain. Neuropharmacology, 49, 230-242, 2004.
- Hamlin A.S., Buller K., Day T.A. and Osborne P.B., Effect of naloxone precipitated morphine withdrawl on c-fos expression in rat CRH neurons in the paraventricular hypothalamus and extended amygdala. Neuroscience Letters, 362, (1), 39-43, 2004.
- Hamlin A.S., Buller K., Day T.A. and Osborne P.B., Peripheral withdrawal recruits distinct central nuclei in morphine-dependent rats. Neuropharmacology, 41, 574 – 581, 2001.
Hamlin A.S., The neurobiology of religious experience. In: The Australian book of atheism. Bonnet W (ed), Scribe, Victoria, Australia. ISBN (13): 9781921640766, 2010.
- 2013 – The role of the cholinergic system in early Alzheimer's disease. Anatomy and Neuroscience Seminar Series, School of Medicine, University of Melbourne, Australia
- 2011- Behavioural and Magnetic Resonance detection of cholinergic basal forebrain degeneration. Centre for Research into Complex Systems, Bathurst, Australia
- 2010 - Use of MR for the early detection of Alzheimer's disease. Translational Research Excellence 2010, Brisbane, Australia
- 2010 - The role of basal forebrain cholinergic neurons in spatial memory, 3rd Brain Plasticity Symposium: Circuits, Synapses and Behaviour, Queensland Brain Institute, Brisbane, Australia
- 2009 - Mechanisms and early detection of cholinergic basal forebrain neurodegeneration, Statewide Dementia Clinical Network Forum, Brisbane, Australia
- 2007 - The neural correlates of context triggered renewal of extinguished reward-seeking, Neuroscience Seminar Series, The University of Newcastle, Newcastle, Australia
- 2007 - Neural circuitry underlying renewal of extinguished cocaine-seeking, Brain Sciences UNSW Symposium, The University of New South Wales, Sydney, Australia
- 2006 - Neural correlates of contextual renewal to alcohol and cocaine seeking behaviour, Australian Learning Group Workshop, Sydney, Australia
- 2005 - The role of the central amygdala in acute morphine abstinence induced hyperalgesia, Kolling Institute Seminar Series, Royal North Shore Hospital, Sydney, Australia
- 2003 - Repeated morphine administration in rats alters Fos expression in the ventromedial striatum and nucleus accumbens, produces tolerance to catalepsy and sensitises stereotypy. XI Annual Royal North Shore Scientific Meeting, Sydney, Australia
- 2003 - Differential expression of Fos and c-Fos immunoreactive nuclei in the rat forebrain by acute morphine challenge in chronically pre-treated animals. Gene Regulation in Brain, Heron Island, Australia
Member of the Brain Behaviour Research Group
Member of the Society for Neuroscience
Member of the Australian Neuroscience Society