Further Publications

Dr Brendan Wilkinson

  1. McDonald, D. M., Wilkinson, B. L., Corcilius, L., Thaysen-Andersen, M., Byrne, S. N., Payne. R. J. Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates. Chem. Commun. 2014, 50, 10273-10276.
  2. Huma, Z. E., Ludeman, J. P., Wilkinson, B. L., Payne, R. J., Stone, M. J. NMR characterization of cooperativity: Fast ligand binding coupled to slow protein dimerization. Chem. Sci. 2014, 5, 2783-2788.
  3. Hsieh, Y.S.Y., Wijeyewickrema, L. C., Wilkinson, B. L., Pike, R. N., Payne, R. J. Total synthesis of homogeneous variants of hirudin P6: A post-translationally modified anti-thrombotic leech-derived protein. Angew.Chem. Int. Ed. 2014, 53 (15), 3947-3951.
  4. Al Sheikha, D., Wilkinson, B. L., Santhakumar, G., Thaysen-Andersen, M., Payne, R. J. Synthesis of homogeneous MUC1 oligomers via a bi-directional ligation strategy. Org. Biomol. Chem. 2013, 11, 6090-6096.
  5. Roche, M., Halimi, S., Duncan, R.,Wilkinson, B. L. et. al. A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations. Retrovirology 2013, 10 (43), 1-20.
  6. Wilkinson, B. L. 1-(Acyloxy)benzotriazoles: Useful Reagents for the Regioselective Acylation of Diols. Aust. J. Chem. 2013, 66 (8), 910-912.
  7. Wilkinson, B. L., Day, S., Chapman, R., Perrier, S., Apostolopoulos, V., Payne, R. J. Synthesis and immunological evaluation of self-assembling and self-adjuvanting tricomponent glycopeptide cancer-vaccine candidates. Chem. Eur. J. 2012, 18 (51), 16540-16548.
  8. Hsieh, Y. S. Y., Taleski, D., Wilkinson, B. L., Wijeyewickrema, L. C., Adams, T. E., Pike, R. N., Payne, R. J. Role of O-Glycosylation and Tyrosine Sulfation on Leech-Derived Peptides for Binding and Inhibitory Activity against Thrombin. Chem. Commun. 2012, 48, 1547-1549.
  9. Hsieh, Y.S.Y., Wilkinson, B. L., O'Connell, M. R., MacKay, J. P., Matthews, J. M., Payne, R. J. Synthesis of the bacteriocin glycopeptide sublancin 168 and S-glycosylated variants. Org. Lett. 2012, 14 (7), 1910-1913.
  10. Moeker, J., Teruya, K., Rossit, S., Wilkinson, B. L., Lopez, M., Bornaghi, L. F., Innocenti, A., Supuran, C. T., Poulsen, S. –A. Design and synthesis of thiourea compounds that inhibit transmembrane anchored carbonic anhydrases. Bioorg. Med. Chem. 2012, 20 (7), 2392-2404.
  11. Wilkinson, B. L. Stone, R. S., Capicciotti, C. J. Thaysen-Andersen, M., Matthews, J. M., Packer, N. H., Ben, R. N., Payne, R. J.  Total synthesis of homogeneous antifreeze glycopeptides and glycoproteins. Angew. Chem. 2012, 51 (15), 3606-3610.
  12. Wilkinson, B. L., Day, S., Malins, L., Apostolopoulos, V., Payne, R. J.Self-adjuvanting Multi-component Cancer Vaccine Candidates Combining Per-glycosylated MUC1 Glycopeptides and the Toll-like Receptor 2 Agonist Pam3CysSer. Angew. Chem. Int. Ed. 2011, 50, 1635-1639.
  13. Thaysen-Anderson, M., Wilkinson, B. L., Payne, R. J., Packer, N. Site-specific Characterisation of Densely Glycosylated Mucin-type Peptides using Electron Transfer Dissociation ESI-MS/MS. Electrophoresis 2011, 32, 3536–3545.
  14. Barker, M. K., Wilkinson, B. L., Faridmoayer, A., Scaman, C. H., Fairbanks, A. J., Rose, D. R. Protein Expres. Purif. 2011, 79, 96-101.
  15. Wilkinson, B. L., Chun, C. K. Y., Payne, R. J.; Synthesis of MUC1 thioesters and ligation by direct aminolysis. Biopolymers: Pept. Sci. 2011, 96 (2), 137-146.
  16. Wilkinson, B. L., Malins, L. R., Chun, C. K., Payne R. J. Synthesis of MUC1-lipopeptide chimeras. Chem Commun. 2010, 46 (34), 6249-6251.
  17. Wilkinson, B.L.; Bornaghi, L.F. Lopez, M.; Healy, P.C.; Poulsen, S.-A.; Houston, T.A. Synthesis of N-Propargyl Azasugar Scaffolds for Compound Library Generation using Click Chemistry. Aust. J. Chem. 2010, 63, 821-829.
  18. van Dijkum, E.; Danac, R.; Hughes, D.; Wilkinson, B. L.; Fairbanks, A. J. Synthesis of glucose derivatives modified at the 4-OH position as potential chain-terminators of cellulose biosynthesis; herbicidal activity of simple monosaccharide derivatives. Org. Biomol. Chem. 2009, 7, 1097-1105.
  19. Yeoh, K. K.; Butters, T. D.; Wilkinson, B. L.; Fairbanks, A. J. Probing Replacement of Pyrophosphate via Click Chemistry; Synthesis of UDP-Sugar Analogues as Potential Glycosyl Transferase Inhibitors. Carbohydr. Res.2009, 344, 586-591.
  20. Ayers, B.; Wilkinson, B. L.; Sim, E.; Long, H.; Fairbanks, A. J. Stereoselective synthesis of beta-arabino glycosyl sulfones as potential inhibitors of mycobacterial cell wall biosynthesis. Carbohydr. Res. 2009, 344, 739-746.
  21. Wilkinson, B. L.; Long, H.; Sim, E.; Fairbanks, A. J. Synthesis of Arabino Glycosyl Triazoles as Potential Inhibitors of Mycobacterial Cell Wall Biosynthesis. Bioorg. Med. Chem. Lett. 2008, 18 (23), 6265-6267.
  22. Poulsen S. A.; Wilkinson B. L.; Innocenti A.; Vullo D.; Supuran C. T. Carbonic anhydrase inhibitors: Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureido-sulfonamides. Bioorg. Med. Chem. Lett.2008, 18 (16), 4624-7.
  23. Wilkinson, B. L.; Fairbanks, A. J. One-pot synthesis of carbohydrate thionolactones from 1-thiosugars. Tetrahedron Lett. 2008, 49, 4941-4943.
  24. Wilkinson, B. L.; Innocenti A.; Vullo, D; Supuran C. T.; Poulsen, S. –A.; Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides. J. Med. Chem. 2008, 51 (6), 1945-1953.
  25. Wilkinson, B. L., Bornaghi, L. F., Houston, T. A., Innocenti, A., Vullo, D., Supuran, C. T., Poulsen, S. -A. Carbonic anhydrase inhibitors: Inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides. J. Med. Chem. 2007, 50 (7),1651-1657.
  26. Wilkinson, B. L., Bornaghi, L. F., Houston, T. A., Innocenti, A., Vullo, D., Supuran, C. T., Poulsen, S. –A. Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides. Bioorg. Med. Chem. Lett. 2007, 17 (4), 987-992.
  27. Wilkinson, B. L.; Bornaghi, L. F.; Wright, A. D.; Houston, T. A.; Poulsen, S. –A. Antimycobacterial activity of a bis-sulfonamide. Bioorg. Med. Chem. Lett. 2007, 17 (5), 1355-1357.
  28. Wilkinson, B. L.; Bornaghi, L. F.; Houston, T. A.; Innocenti, A.; Supuran, C. T.; and Poulsen, S. –A. A novel class of carbonic anhydrase inhibitor: glycoconjugate benzene sulfonamides prepared by “click-tailing” J. Med. Chem. 2006, 49 (22), 6539-6548.
  29. Wilkinson, B. L.; Bornaghi, L. F.; Poulsen, S. –A.; Houston, T. A. Synthetic utility of glycosyl triazoles in carbohydrate chemistry Tetrahedron 2006, 62 (34), 8115–8125.
  30. Wilkinson, B. L. B., L.F.; Houston, T. A.; Poulsen, S. -A.; White, A. R. 4-Hydroxymethyl-1-(2',3',4',6'-tetra-O-acetyl-ß-D-glucopyranosyl)-1,2,3-triazole. Acta Crystallographica, Section E: Structure Reports Online 2006, E62, o5065-o5067.
  31. Wilkinson, B. L.; Bornaghi, L. F.; Houston, T. A.; Poulsen, S. -A, Healy, P. C.   Methyl 2,3,4-tri-O-acetyl-1-azido-1-deoxy-β -D-glucopyranuronate at room temperature.    Acta Crystallographica, Section E: Structure Reports Online 2005, E61(3), o738-o740.
  32. Bornaghi, L. F.; Wilkinson, B.  L.; Kiefel, M. J.; Poulsen, S. -A.   Synthesis of cyclic oligomers of a modified sugar amino acid utilising dynamic combinatorial chemistry. Tetraherdon Lett. 2004, 45 (50), 9281-9284.
  33. Houston, T. A., Wilkinson, B. L., Blanchfield, J. T. Boric acid-catalyzed chemoselective esterification of α -hydroxycarboxylic acids. Org. Lett. 2004, 6 (5), 679-681.