Low dose X-ray phase-contrast imaging and tomography

Project title: Low dose X-ray phase-contrast imaging and tomography

Principal investigator:A/Prof. Konstantin Pavlov (UNE)

PhD Student:Mr Darren Thompson

Other participants: Dr T.E. Gureyev (UNE, Melbourne University, CSIRO, Monash University), Dr Y.I. Nesterets (UNE, CSIRO), Dr G. Tromba (ELETTRA), Dr S.C. Mayo (CSIRO), Dr A.W. Stevenson (CSIRO), Dr M.J. Kitchen (Monash University).

Project description:
Phase-contrast imaging is the future of X-ray imaging. This powerful type of X-ray imaging, which makes use of free-space propagation as well as optical elements made of perfect crystals, is specially tailored to image samples which are invisible to conventional X-ray techniques. Such "extended X-ray vision" is extremely important for imaging in medicine, biology and materials science. These techniques reveal the internal structure of low-absorption materials, where traditional X-ray radiography methods often struggle to provide sufficient contrast. In particular, this project is focused on development of low-dose high-sensitivity three-dimensional mammographic phase-contrast imaging, initially at synchrotrons and subsequently in hospitals and medical imaging clinics.

Related publications:

  1. G. Tromba, S. Pacilè , Y.I. Nesterets, F. Brun, C. Dullin, D. Dreossi, S.C. Mayo, A.W. Stevenson, K.M. Pavlov, M.J. Kitchen, D. Thompson, J.M.C. Brown, D. Lockie, M. Tonutti, F. Stacul, F. Zanconati, A. Accardo and T.E. Gureyev. Phase-contrast clinical breast CT: optimization of imaging setups and reconstruction workflows. Lecture Notes in Computer Science, v. 9699, p. 625-634 (2016)
  2. Y.I. Nesterets, T.E. Gureyev, S.C. Mayo, A.W. Stevenson, D. Thompson, J.M.C. Brown, M.J. Kitchen, K.M. Pavlov, D. Lockie and G. Tromba. A feasibility study of X-ray phase-contrast mammographic tomography at the Imaging and Medical beamline of the Australian Synchrotron. J. Synchr. Rad. 22, 1509-1523 (2015). (IF=2.794)
  3. P. Vagovic, L. Sveda, A. Cecilia, E. Hamann, D. Pelliccia, E. N. Gimenez, D. Korytar, K. M. Pavlov, Z. Zaprazny, M. Zuber, T. Koenig, M. Olbinado, W. Yashiro, A. Momose, M. Fiederle, and T. Baumbach. X-ray Bragg Magnifier Microscope as a linear shift invariant imaging system: image formation and phase retrieval. Optics Express  22(18), 21508-21520 (2014). (IF=3.488)
  4. T E Gureyev, S C Mayo, Ya I Nesterets, S. Mohammadi, D Lockie, R H Menk, F Arfelli, K M Pavlov, M J Kitchen, F Zanconati, C Dullin and G Tromba. Investigation of the imaging quality of synchrotron-based phase-contrast mammographic tomography. J. Phys. D: Appl. Phys.  47, 365401 (2014). (IF=2.721)
  5. T.W. Baillie, T.E. Gureyev, J.A. Schmalz, and K.M. Pavlov. Phase-contrast X-ray tomography using Teague's method. Optics Express 20(15), 16913-16925 (2012). (IF=3.488)
  6. J.A. Schmalz, T.E. Gureyev, D.M. Paganin, K.M. Pavlov. Phase retrieval using radiation and matter wave fields: Validity of Teague's method for solution of the transport of intensity equation. Physical Review A 84, 023808 (2011). (IF=2.808)
  7. M.J. Kitchen, D.M. Paganin, K. Uesugi, B.J. Allison, R.A. Lewis, S.B. Hooper, K.M. Pavlov. Phase contrast image segmentation using a Laue analyser. Phys. Med. Biol. 56, 515-534 (2011). (IF=2.761)
  8. M.J. Kitchen, D.M. Paganin, K. Uesugi, B.J. Allison, R.A. Lewis, S.B. Hooper and K.M. Pavlov. X-ray phase, absorption and scatter retrieval using two or more phase contrast images. Optics Express 18(19), 19994-20012 (2010). (IF=3.488)
  9. J.A. Schmalz, G. Schmalz, T.E. Gureyev and K.M. Pavlov. On the derivation of the Green function for the Helmholtz equation using generalized functions. American J. Phys 78(2), 181-186 (2010).
  10. D.J. Vine, D. M. Paganin, K. M. Pavlov, K. Uesugi, A. Takeuchi, Y. Suzuki, N. Yagi, T. Kämpfe, E.-B. Kley, E. Förster. Deterministic Green's function retrieval using hard X-rays. Phys. Rev. Lett. 102, 043901 (2009).  (IF=7.512)
  11. M.J. Kitchen, K.M. Pavlov, S.B. Hooper, D.J. Vine, K.K.W. Siu, M.J. Wallace, M.L.L. Siew, N. Yagi, K. Uesugi, R.A. Lewis. Simultaneous acquisition of dual analyser-based phase contrast X-ray images for small animal imaging, Eur J. Radiol, 68S, S49-S53 (2008). (IF=2.369)
  12. D. J. Vine, D. M. Paganin, K. M. Pavlov, J. Kräußlich, O. Wehrhan, I. Uschmann, and E. Förster. Analyser-based phase contrast imaging and phase retrieval using a rotating anode X-ray source. Appl. Phys. Lett. 91, 254110 (2007). (IF=3.302)
  13. S.B. Hooper, M.J. Kitchen, M.J. Wallace, N. Yagi, K. Uesugi, M.J. Morgan, C. Hall, K.K.W. Siu, I.M. Williams, M. Siew, S.C. Irvine, K. Pavlov, R.A. Lewis. Imaging lung aeration and lung liquid clearance at birth. FASEB (The Journal of the Federation of American Societies for Experimental Biology) 21, 3329-3337 (2007). (IF=5.043)
  14. M.J. Kitchen, K.M. Pavlov, K.K.W. Siu, R.H. Menk, G. Tromba, R.A. Lewis. Analyser-based phase-contrast image reconstruction using geometrical optics. Phys.Med. Biol. 52, 4171 -4187 (2007). (IF=2.761)
  15. D.J. Vine, D.M. Paganin, K.M. Pavlov, and S.G. Podorov. Unambiguous reconstruction of the complex amplitude reflection coefficient of a laterally homogeneous crystal using analyser-based phase-contrast imaging. J. Appl. Cryst. 40, 650-657 (2007). (IF=3.984)
  16. T.E. Gureyev, Ya.I. Nesterets , K.M. Pavlov and S.W. Wilkins.  Computed tomography with linear shift-invariant optical systems. J. Opt. Soc. Am. A. 24(8), 2230-2241 (2007). (IF=1.558)
  17. Ya.I. Nesterets, T.E. Gureyev, K.M. Pavlov, D.M. Paganin, S.W. Wilkins Combined analyser-based and propagation-based phase-contrast imaging of weak objects. Opt. Comm., 259(1), 19-31 (2006). (IF=1.449)
  18. K. M. Pavlov, T. E. Gureyev, D. Paganin, Y. I. Nesterets, M. Kitchen, K. K.W. Siu, J. Gillam, K. Uesugi, N. Yagi, M. J. Morgan, R. A. Lewis. Unification of analyser-based and propagation-based X-ray phase-contrast imaging. Nucl. Instr. And Meth. A 548, 163-168 (2005). (IF=1.216)
  19. R.A. Lewis, N. Yagi, M.J. Kitchen, M.J. Morgan, D. Paganin, K.K.W. Siu, K. Pavlov, I. Williams, K. Uesugi, M.J.Wallace, C.J. Hall, J. Whitley, S.B. Hooper. Dynamic imaging of the lungs using X-ray phase contrast. Phys. Med. Biol. 50, 5031-5040 (2005). (IF=2.761)
  20. D. Briedis, K.K.W. Siu, D.M. Paganin, K.M. Pavlov and R.A. Lewis. Analyser-based mammography using single-image reconstruction. Phys. Med. Biol., 50 3599-3611 (2005). (IF=2.761)
  21. M.J. Kitchen, R.A. Lewis, N. Yagi, K. Uesugi, D. Paganin, S.B. Hooper, G. Adams, S. Jureczek, J. Singh, C.R. Christensen, A.P. Hufton, C.J. Hall, K.C. Cheung, and K.M. Pavlov. Phase contrast X-ray imaging of mice and rabbit lungs: a comparative study. British J. Radiology. 78, 1018-1027 (2005). (IF=2.026)
  22. K. K.W. Siu, M. J. Kitchen, K.M. Pavlov, John. E. Gillam, R.A. Lewis, K. Uesugi, N. Yagi. An improvement to the diffraction enhanced imaging method that permits imaging of dynamic systems. Nucl. Instr. And Meth. A 548, 169-174 (2005). (IF=1.216)
  23. S. Rigley, L. Rigon, K. Ataelmannan, D. Chapman, R. Doucette, R. Griebel, B. Juurlink, F. Arfelli, R. Menk, G. Tromba, R.C. Barroso, T. Beveridge, R. Lewis, K. Pavlov, K. Siu, C. Hall, E. Schültke,.  Absorption edge substraction imaging for volumetric measurement in an animal model of malignant brain tumor. Nucl. Instr. And Meth. A 548, 88-93 (2005). (IF=1.216)
  24. K.A. Mannan, E. Schültke, R.H. Menk, K. Siu, K. Pavlov, M. Kelly, G. McLoughlin, T. Beveridge, G. Tromba, B.H. Juurlink, D. Chapman, L. Rigon, R.W. Griebel. Synchrotron supported DEI/KES of a brain tumor in an animal model: The search for a microimaging modality. Nucl. Instr. And Meth. A 548, 106-110 (2005). (IF=1.216)
  25. K.M. Pavlov, T.E. Gureyev, D. Paganin, Ya.I. Nesterets, M.J. Morgan, and R.A. Lewis, Linear systems with slowly varying transfer functions and their application to X-ray phase-contrast imaging. J. Phys. D: Appl. Phys. 37, 2746-2750 (2004). (IF=2.721)
  26. Ya.I. Nesterets, T.E. Gureyev, D. Paganin, K.M. Pavlov, S.W. Wilkins, Quantitative diffraction-enhanced X-ray imaging of weak objects. J. Phys. D: Appl. Phys. 37, 1262-1274 (2004). (IF=2.721)
  27. D. Paganin, T.E. Gureyev, K.M. Pavlov, R.A. Lewis, M. Kitchen, Phase retrieval using coherent imaging systems with linear transfer functions. Opt. Commun., 234, 87-105 (2004). (IF=1.449)
  28. Pavlov, K.M., Kewish, C.M., Davis, J.R. and Morgan, M.J. A variant on the geometrical optics approximation in diffraction enhanced tomography. J. Phys. D: Appl. Phys. 34, A168-A172 (2001). (IF=2.721)
  29. Kewish, C.M., Davis, J.R., Nikulin, A.Y., Benci, N., Pavlov, K.M., Morgan, M.J., and Hester, J.R. Implementation of an analyser crystal method for X-ray diffraction tomography. J. Phys. D: Appl.Phys. 34, 1059-1064 (2001). (IF=2.721)
  30. Pavlov, K.M., Kewish, C.M., Davis, J.R. and Morgan, M.J. A simple method for estimating linear attenuation coefficients from X-ray diffraction tomography data. Rev. Sci. Instrum. 72, 1918-1920 (2001). (IF=1.614)
  31. Pavlov, K.M., Kewish, C.M., Davis, J.R. and Morgan, M.J. A new theoretical approach to X-ray diffraction tomography. J. Phys. D: Appl. Phys. 33, 1596-1605 (2000). (IF=2.721)