Palladium-Catalyzed Suzuki–Miyaura, Heck and Hydroarylation Reactions on (–)-Levoglucosenone and Application to the Synthesis of Chiral γ-Butyrolactones

Palladium-Catalyzed Suzuki–Miyaura, Heck and Hydroarylation Reactions on (–)-Levoglucosenone and Application to the Synthesis of Chiral γ-Butyrolactones
European Journal of Organic Chemistry, 2015, 2015(32), 6999-7008
K. P. Stockton, C. J. Merritt, C.J. Sumby and B. W. Greatrex

This article describes new ways to derivatise levoglucosenone, a readily available chiral synthon which is available in bulk from the pyrolysis of lignocellulose. The derivatives produced will be used in the synthesis of chiral pharmaceuticals and industrial chemicals.