Linda Agnew
Senior Lecturer, School of Science and Technology
Qualifications
BSc (UNE), BSc (Hons) (UNE), PhD (UNE)
Contact
| Email: | lagnew2@une.edu.au |
| Room: | McClymont Building (W34) 353 |
| Phone: | 02 6773 2631 (or +61 2 6773 2631 overseas) |
| Fax: | 02 6773 3267 |
My general interest in Biomedical Sciences began with my BSc (Hons) in 2003 and PhD (2005) degrees at the University of New England. This interest was further developed during my postdoctoral fellowship at CSIRO. My independent academic career commenced in 2009 at the University of New England. My research has included multi-colour flow cytometric analysis of differential leukocyte heat shock protein 70 (hsp70) expression. This work highlighted that leukocyte hsp70 expression is intricately associated with immune function and is altered A) in response to viral infection, B) as a result of herbal supplementation with Echinacea and C) in response to immunological changes that occur during the menstrual cycle and with oral contraceptive use. The experimental work conducted to date has provided evidence of a number of different factors that modulate hsp70 expression in human leukocytes.
Affiliations
Member of the Centre for Bioactive Discovery in Health and Ageing
Research interests
My five main areas of current research investigation are:
- Immunological and stress responses in health and disease
- Immunological responses to herbal medications
- Bi-directional communication between the HPA axis & immune system
- Oxidative stress and antioxidant status
- Long-term non-progression in HIV-disease
Teaching
Microbiology
Human nutrition
Immunology
Selected publications
Book Chapters
Agnew LL and Watson K., Detection of stress proteins as biomarkers of oxidative stress, In Current Protocols in Toxicology, Chapter 17, pp. 1 – 26, M.D. Maines, L.G. Costa, D.J. Reed, S. Sassa, I.G. Sipes (Eds.), John Wiley & Sons, Inc., New York, 2006.
Journal articles
Agnew LL and Colditz IG, Development of a method of measuring cellular stress in sheep and cattle, Veterinary Immunology and Immunopathology, 123 (3-4): 197 – 204, 2008.
Andrews C, Matthias A, Agnew LL, Reinke N, Watson K, Bone KM and Lehmann RP, Enhanced antioxidant effect of herbal-nutrient complex including ascorbic acid and Polygonum cuspidatum extract (containing resveratrol), The Australian Journal of Medical Herbalism, 19(4), 2007.
Matthias A, Addison RS, Agnew LL, Bone KM, Watson K and Lehmann RP, Comparison of Echinacea alkylamide pharmacokinetics between liquid and tablet preparations, Phytomedicine, 14, pp. 587 – 590, 2007.
Agnew LL, Guffogg SP, Matthias AM, Lehmann RP, Bone K and Watson K, Echinacea intake induces an immune response through altered expression of leukocyte hsp70, increased white cell counts and improved erythrocyte antioxidant defences, Journal of Clinical Pharmacy and Therapeutics, 30: 363-369, 2005.
Agnew LL, Kelly M, Batterham M, Ffrench R, Gold J and Watson K., Altered lymphocyte heat shock protein 70 expression in patients with HIV disease, AIDS 2003, 17(13): 1985-1988.