Dr Daniel Keddie
Lecturer, School of Science and Technology
Qualifications
BAppSc (Hons), PhD (QUT),
Contact
| Email: | daniel.keddie@une.edu.au |
| Room: | Riggs Building (C23) 202 |
| Phone: | 02 6773 2912 (or +61 2 6773 2912 overseas) |
| Fax: | 02 6773 3268 |
Dr Daniel Keddie has recently commenced as Lecturer of Organic Chemistry in the School of Science and Technology.
Dr Keddie obtained his PhD in synthetic organic chemistry in 2008 from the School of Physical and Chemical Sciences, Queensland University of Technology (QUT), where he worked on the synthesis of profluorescent nitroxides under the supervision of Professor Steven Bottle. This work involved the multistep synthesis of novel isoindoline nitroxide radicals bearing fluorescent and/or water solubilizing functionality, primarily using palladium catalysis techniques to build key structures.
He subsequently undertook a postdoctoral position at the Institute of Health and Biomedical Innovation (IHBI), QUT, where his work focussed on the synthesis and characterization of amphiphilic siloxane copolymers, including the development of a new protocol for the preparation of discrete silicone-based surfactants.
From October 2009 until recently, Dr Keddie held an OCE postdoctoral fellowship at the Commonwealth Scientific and Industrial Research Organization, Australia (CSIRO). During this time he worked with Dr Graeme Moad, co-inventor of the reversible addition-fragmentation chain transfer (RAFT) process, on the design and synthesis of “switchable” chain transfer agents.
Affiliations
MRACI, MACS
Areas of Teaching
CHEM110 (Chemistry I)
CHEM120 (Chemistry II)
CHEM204 (Biological and Organic Chemistry)
CHEM302 (Organic Structure and Reactivity)
Research interests
Dr Keddie’s research interests include free radical chemistry, transition metal catalysis, high-throughput experimentation and the synthesis and application of novel functional small molecules and polymers.
Selected Publications
Keddie D.J., Moad G., Rizzardo E. and Thang S.H., “RAFT agent design and Synthesis” Macromolecules, 45, 5321-5342, 2012.
Keddie D.J., Guerrero-Sanchez C., Moad G., Mulder R.J., Rizzardo E. and Thang S.H., “Chain Transfer Kinetics of Acid/Base Switchable N-Aryl-N-Pyridyl Dithiocarbamate RAFT Agents in Methyl Acrylate, N-Vinylcarbazole and Vinyl Acetate Polymerization”, Macromolecules, 45, 4205-4215, 2012.
Houshyar S., Keddie D.J., Moad G., Mulder R.J., Saubern S. and Tsanaktsidis J., “The scope for synthesis of Macro-RAFT Agents by Sequential Insertion of Single Monomer Units”, Polymer Chemistry, 3, 1879-1889, 2012.
Furrugia B.L., Keddie D.J., George G.A., Lynam E.C., Brook M.A., Upton Z. and Dargaville T.R., “An investigation into the effect of amphiphilic siloxane oligomers on dermal fibroblasts”, Journal of Biomedical Materials Research: Part A, 100A (7), 1919-1927, 2012.
Keddie D.J., Guerrero-Sanchez C., Moad G., Rizzardo E. and Thang S.H., “Switchable Reversible Addition-Fragmentation Chain Transfer (RAFT) polymerization in aqueous solution, N,N-Dimethylacrylamide”, Macromolecules, 44 (17), 6738-6745, 2011.
Keddie D.J., Grande J.B., Gonzaga F., Brook M.A. and Dargaville T.R., “Amphiphilic Silicone Architectures via Anaerobic Thiol–Ene Chemistry”, Organic Letters, 13 (22), 6006-6009, 2011.
Morrow B.J., Keddie D.J., Gueven N., Lavin M.F. and Bottle S.E., “A novel profluorescent nitroxide as a sensitive probe for the cellular redox environment”, Free Radical Biology and Medicine, 49 (1), 67-76, 2010.
Keddie D.J., Fairfull-Smith K.E. and Bottle S.E., “The Palladium-Catalyzed Copper-Free Sonogashira Coupling of Isoindoline Nitroxides: A Convenient Route to Robust Profluorescent Carbon-Carbon Frameworks”, Organic & Biomolecular Chemistry, 6(17), 3135-3143, 2008.
Fairfull-Smith K.E., Blinco J.P., Keddie D.J., George G.A. and Bottle S.E., “A Novel Profluorescent Dinitroxide for Imaging Polypropylene Degradation”, Macromolecules, 41(5), 1577-1580, 2008.
Keddie D.J., Johnson T.E., Arnold D.P. and Bottle S.E, “Synthesis of Profluorescent Isoindoline Nitroxides via Palladium-Catalyzed Heck Alkenylation”, Organic & Biomolecular Chemistry, 3(14), 2593-2598, 2005.