Dr Linda Agnew
Senior Lecturer - School of Science & Technology
Phone: +61 2 6773 2631
Dr Linda Agnew is a cellular immunologist with expertise in the measurement and analysis of biomarkers of the immunological and cellular stress responses in health and disease. While the primary focus of this research is core biomedical science much of its application is in clinical medicine providing translational (bench-to-bedside) outcomes.
BSc (Hons) (UNE), PhD (UNE)
Brain Behaviour Research Group
Centre for Bioactive Discovery in Health and Ageing
Centre for Autism Spectrum Disorders
Core research techniques used in my laboratory can be applied to assess a wide range of immunological processes (and by definition healthy vs. pathological states). The nature of my research, therefore, enables its application to a wide range of research projects that currently include:
- Bi-directional communication between the HPA axis & immune system (in depression)
- The role of basophils in the Th2 immune response
- The cellular stress response in Coeliac Disease
- Immunological responses to herbal medications
- Oxidative stress and antioxidant status
See also ResearchGate
Bitsika V, Sharpley CF, Andronicos NM, Agnew LL. (2015) Hypothalamus Pituitary Adrenal Axis daily fluctuation, anxiety and age interact to predict cortisol concentrations in boys with an Autism Spectrum Disorder. Physiology and Behavior 138: 200 – 207.
Corvan SM, Agnew LL, Andronicos NM. (2014) Trichostrongylus colubriformis induces IgE-independent CD13, CD164 and CD203c mediated activation of basophils in an in vitro intestinal epithelial cell co-culture model. Veterinary Parasitology doi:10.1016/j.vetpar.2014.10.012
Iseme RA, McEvoy M, Kelly B, Agnew LL, Attia J, Walker FR. (2014) Autoantibodies and depression evidence for a causal link? Neuroscience and Biobehavioral Reviews. 40: 62-79.
Sharpley CS, Palanisamy SAK, Glyde NS, Dillingham P, Agnew LL. (2014)An update on the interaction between the Serotonin Transporter Promoter Variant (5-HTTLPR), Stress and Depression, plus an Exploration of Non-confirming Findings. Behavioural Brain Research 273: 89 – 105.
Sharpley CF, Agnew LL. (2011) Cytokines and Depression: Findings, Issues and Treatment Implications. Reviews in the Neurosciences, Vol. 22(3): 295–302.
Agnew LL. (2011) Measuring Intracellular HSP70 in Leukocytes by Flow Cytometry. Current Protocols in Toxicology, Supplement 2:21. DOI: 10.1002/0471140856.tx0221s49. 100%
Agnew LL and Colditz IG (2008) Development of a method of measuring cellular stress in sheep and cattle, Veterinary Immunology and Immunopathology, 123 (3-4): 197 – 204,.
Agnew LL and Watson K. (2006) Detection of stress proteins as biomarkers of oxidative stress, In Current Protocols in Toxicology, Chapter 17, pp. 1 – 26, M.D. Maines, L.G. Costa, D.J. Reed, S. Sassa, I.G. Sipes (Eds.), John Wiley & Sons, Inc., New York,.
Agnew LL, Guffogg SP, Matthias AM, Lehmann RP, Bone K and Watson K. (2005) Echinacea intake induces an immune response through altered expression of leukocyte hsp70, increased white cell counts and improved erythrocyte antioxidant defences, Journal of Clinical Pharmacy and Therapeutics, 30: 363-369.
Agnew LL, Kelly M, Batterham M, Ffrench R, Gold J and Watson K. (2003) Altered lymphocyte heat shock protein 70 expression in patients with HIV disease, AIDS, 17(13): 1985-1988.