Graham Jones

Associate Professor - School of Science & Technology

Graham Jones

Phone: +61 2 6773 3274

Email: gjones2@une.edu.au

Biography

Additional:Convenor of Human Biology and Physiology
Conjoint A/Professor, University of Newcastle (Australia) (JMP)
Visiting Fellow, University of Exeter (UK) 1997 and 2004

Graham has been involved in a wide range of research programmes applying basic chemical, biochemical and immunological techniques to the study of human biology. During an active research career spanning several decades he has characterised important polymorphic variants of human carbonic anhydrases and aldehyde dehydrogenases and contributed to a biological understanding of their fitness particularly in Australian Aboriginal populations. He characterised a variant Band 3 protein in PNG populations and showed how this variant protein serves to alter red cell shape to produce characteristic malaria resistant ovalocytes. He was part of the Saramane consortium developing peptide based immunogens as part of a malaria vaccine programme. He has developed protein fingerprints for hair analysis in humans and animals which may be of forensic interest. Projects involving Blackmores Aust as industry partner have focused on the role of antioxidants in the mitigation of skin damage after UV exposure.

More recent research interests have focused on investigations of the effects of antioxidant supplements on age related attenuation of the stress protein response as well as changes in this response in human breast cancer particularly with respect to the assembly of stress protein complexes in cell signal transduction.

Recently we have begun investigating useful bioactivities of native Australian plants used traditionally by Aborigines in wound healing.

Qualifications

BSc (Hons), PhD (Qld)

Teaching Areas

  • Discipline lead in Biochemistry and Immunology in JMP (joint rural medical programme) FRS and PBL presenter
  • MICR350 Clinical Microbiology and Virology
  • HHSC384 The Biology of Human Ageing
  • HHSC243 Cellular and Molecular Mechanisms of Disease (Human Genetics and Cancer modules)
  • HHSC146 Fundamentals of Health Science 1
  • FSC102 Fundamentals in Forensic Science (Hair and fibre analysis as well as drugs analysis modules)

Research Interests

  • Human hair and erythrocyte membrane proteins.
  • Stress proteins in human ageing and cancer.
  • Bioremediation of depleted agricultural and pastoral land.
  • Science education for students of the complementary therapies
  • Bioactivities of traditional Aboriginal medicinal plants

Publications

Selected publications

Smith J.E., Watson K., Tucker D. and Jones G.L., Identification of antibacterial constituents from the Australian medicinal plant Eremophila duttonii (F. Muell) (Myoporaceae), J. Ethnopharmacology, 112: 386-393, 2008.

Jones G.L., Smith J.E. and Watson K., Bioactive properties of native Australian medicinal plants, Acharya S. N., and Thomas J. E., eds, Advances in Medicinal Plant Research, Chapter 12, pp. 257-286, ISBN 81-7736-255-0, Research Signpost, Kerala, 2007.

Jones G.L., Asia and Australia - Essentially a well oiled connection, Dung N. X., Jirovetz L., Varshney V. K., eds, Aromatic Plants from Asia, their Chemistry and Application in Food and Therapy, Chapter 17, pp. 247-261, ISBN 978-81-905771-0-6, Har Krishnan Bhalla, India, 2007.

Rao D. V., Boyle G. M., Parsons P.G., Watson K. and Jones G.L., Influence of ageing, heat shock treatment and in vivo total antioxidant status on gene expression profile and protein synthesis in human peripheral lymphocytes, Mechanisms of Ageing and Development, 124: 55-69, 2003.

Jones G.L., Khawar S.L. and Watson K., A polymorphic variation in the sodium dodecyl sulfate-polyacrylamide gel electrophoresis separation of human hair proteins, Electrophoresis, 20: 3347-3348, 1999.

Jones G.L., Edmundson H., Lord R., Spencer L., Mollard R., and Saul A., Immunological fine structure for the variable and constant regions of a malarial surface antigen, Mol. Biochem. Parasitology, 48: 1-10, 1991.

Jones G.L., Edmundson H.M., Wesche D. and Saul A., Human erythrocyte Band-3 has an altered N terminus in malaria resistant Melanesian ovalocytosis, Biochim. Biophys. Acta., 1096: 33-40, 1990.

Tanner M.J.A., Bruce L., Martin P.G. and Jones G.L., Melanesian hereditary ovalocytes have a deletion in the red cell Band-3 gene, Blood, 78: 2785-2786, 1991.

Jones G.L. and Shaw D.C., Human red cell carbonic anhydrase variants in Australasia, Ann. N.Y. Acad. Sci., 429: 249-261, 1984.

Jones G.L. and Teng Y-s., A chemical and enzymological account of the multiple forms of human liver aldehyde dehydrogenase - Implications for ethnic differences in alcohol metabolism, Biochim. Biophys. Acta., 745: 162-174, 1983.